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Hyaluronic Acid: Benefits, Uses and Differences — From Hydration to Filling in One Read

Hyaluronic acid occurs naturally in the body; 1 gram can carry up to 1,000 times its weight in water. Understanding its benefits and how products differ helps you choose the right treatment.

Hyaluronic Acid: Benefits, Uses and Differences — From Hydration to Filling in One Read

Hyaluronic acid (also known as HA) occurs naturally in the dermis and connective tissue of the human body. It has exceptionally high moisturising capacity — every 1 gram can carry up to 1,000 times its weight in water — and is extremely low in irritation to the skin.

Five key benefits

  • High-efficiency hydration: large molecules stay on the surface to lock in water; medium and small molecules penetrate to the deeper layers of the skin
  • Cell repair: promotes fibroblast activity and speeds wound healing
  • Anti-ageing: replenishes hyaluronic acid lost with age, filling hollows and improving laxity
  • Promotes collagen synthesis: provides moisture for collagen, helping lift and firm
  • Soothes inflammation: improves sensitivity and redness

Cross-linked vs non-cross-linked hyaluronic acid

PropertyCross-linked hyaluronic acidNon-cross-linked hyaluronic acid
Molecular structureCross-linked structure; stableLoose structure; readily broken down
ApplicationFilling hollows, contour shapingHydration and repair, superficial injection
Duration6 to 18 months or moreSeveral weeks to 1 month

Common hyaluronic acid injectables

Hydration type: Neauvia Hydro Deluxe, Profhilo, Restylane Skinboosters, Juvéderm Volite and others.

Filler / contouring type: Juvéderm, Restylane longer-lasting treatments and others, used to fill hollows, improve wrinkles and shape contours.

Side effects and precautions

  • Mild swelling, redness and skin sensitivity at the injection site are common reactions
  • A sensation of lumps may appear at the injection site
  • If injected in the wrong location, there is a risk of blocking a blood vessel and causing skin necrosis — it must be performed by a registered doctor
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